Bringing electrophysiology to light
News
October 21, 2015 - Q-State cofounder Adam Cohen lighted up the brain at the TEDxCambridge conference!
Q-State co-founder Adam Cohen presented Q-State technology and how Q-State trnasforms high-speed movies of electrical impulses traveling through human neurons in a dish to study the molecular basis for a wide array of neuronal diseases.
October 7, 2015 - Nature Methods published a Technology feature about development and use genetically encoded voltage sensors
Q-State co-founder Adam Cohen and Q-State are both quoted.
September 30, 2015 - Graham Dempsey and the Q-State team were awarded at the Safety Pharmacology Society annual meeting
Graham Dempsey and the Q-State team won the 2nd Prize of the Poster Competition at the Safety Pharmacology Society annual meeting.
Prague Congress Centre, Prague, Czech Republic.
September 28-October 1st, 2015 - Q-State Biosciences attended the Safety Pharmacology Society meeting in Prague
Prague Congress Centre, Prague, Czech Republic.
June 30, 2015 - BioCentury Innovations profiled Q-State Biosciences
BioCentury journalist Selina Koch profiled Q-State in BioCentury Innovations and presented Q-State Optical electrophysiology platform for assessing neuronal and cardiac cell function in iPS cellderived disease models.
April 29, 2015 - Q-State Biosciences will attend the 2015 Weinstein conference ( April 30-May 2, 2015)
The John B. Hynes Veterans Memorial Convention Center, Boston MA.
Graham Dempsey, Q-State Biosciences Director of Research and Development will present a poster entitled: "Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging".
April 29, 2015 - Q-State Biosciences will attend ISSCR 2015 in Stockholm (June 24-27, 2015)
Stockholmsmässan Exhibition & Convention Center, Stockholm, Sweden.
April 28, 2015 - Q-State Biosciences will attend BIO 2015 (June 15-18)
The Pennsylvania Convention Center, Philadelphia PA.
April 21, 2015 - Q-State Biosciences co-founder Adam Cohen gives a talk at Stem Cell Network NRW
Adam Cohen gives a talk entitled "All-optical electrophysiology for iPSC neuronal disease modeling" at the 8th International Meeting of the Stem Cell Network NRW held 21-22 April 2015 at the Plenary Chamber at the former German Bundestag in Bonn (Germany).
April 20, 2015 - The ALS Association, Harvard Stem Cell Institute, and Massachusetts General Hospital Neurological Clinical Research Institute Collaborate with GlaxoSmithKline on New ALS Clinical Trial
Q-State co-founder Kevin Eggan committed his lab research program to determining the mechanisms that cause motor neuron degeneration in Amyotrophic Lateral Sclerosis. He confirmed the promise of stem cell disease modeling and the importance of physiology which both led to this ALS clinical trial.
March 23, 2015 - Q-State Biosciences co-founder Adam Cohen receives 2015 ACS Award in Pure Chemistry
The American Chemical Society awarded Adam Cohen for his contributions of major significance to chemistry. Adam is honored for the development of revolutionary techniques using light to image trans-membrane potentials in cells, demonstrate new aspects of Maxwells equations, and immobilize molecules.
March 16, 2015 - Q-State Biosciences and Anagenesis were awarded by Massachussetts Life Sciences Center and Alsace BioValley for their collaborative project on Duchenne Muscular Dystrophy drug discovery
The Massachusetts Life Sciences Center (MLSC) and Alsace BioValley today announced the second round of grants through the MLSC’s International Collaborative Industry Program (ICIP). Q-State and Anagenesis project has been awarded funding for the development of a platform to screen for drugs to treat Duchenne Muscular Dystrophy (DMD), one of the most prevalent inherited diseases in young males.
February 25, 2015 - Q-State Biosciences to attend Bio-Europe Spring 2015 in Paris
Meet us in Paris, France at Paris Expo - Porte de Versailles, Hall 5 on March 9–11, 2015.
January 30, 2015 - Q-State Biosciences partner, Anagenesis Biotechnologies won 1st prize in the 2014 Ubistart contest
Organized by UbiFrance and the International Galien Foundation based in New York, this contest rewards very innovative start-ups in the field of Life Sciences.
December 27-28, 2014 - Q-State Biosciences co-founder Kevin Eggan and Q-State are mentionned in Le Figaro
Le Figaro, the second-largest national newspaper in France, published an article about the dynamism of Boston/Cambridge Hub for Pharma and Biotech. Kevin Eggan and Q-State Biosciences are both quoted.
December 17, 2014 - Bloomberg published an article about Q-State Biosciences technology that Adam E. Cohen developed in his lab at Harvard
Bloomberg published an article entitled "Harvard Scientist Lights Up Neurons to Find Brain Cures" to introduce Harvard University Neuroscientist Adam Cohen’s work and Q-State Biosciences technology.
December 5, 2014 - Q-State Biosciences co-founder Adam E. Cohen and Q-State are mentioned in The Scientist publication
The Scientist published an article entitled "Cutting the Wire, Optical techniques for monitoring action potentials" to introduce different optical alternatives, using light to record and initiate ion-channel activity. Here, Adam Cohen, Q-State co-founder presents Optopatch technology.
November 6, 2014 – Q-State technology is presented in a New Scientist article entitled "This is what brain cell conversations look like"
New Scientist paints Q-State Biosciences technology as a unique tool to eavesdrop on conversations going on between brain cells in a dish.
October 28, 2014 - 1st prize for best poster at NYSC Foundation Research Institute's Ninth Annual Translational Stem Cell Research Conference
Q-State is happy to congratulate Evangelos Kiskinis who was awarded the first prize for best poster at New York Stem Cell Foundation Research Institute's Ninth Annual Translational Stem Cell Research Conference held from October 22 to 23, 2014 in New York, NY. This award recognises the quality of the research performed as presented in the poster session at the conference.
"All Opticall electrophysiology identifies excitability deficits in ALS motor neurons". Evangelos Kiskinis, Joel Kralj, David Margulies, Adam Cohen and Kevin Eggan.
September 29, 2014. Q-State Biosciences and GSK will co-present a poster at Safety Pharmacology Society Annual Meeting
Q-State Biosciences attended SPS Annual Meeting, starting October 19, 2014 at Marriott Wardman Park Hotel in Washington, DC.
Q-State Biosciences co-presented a poster with GlaxoSmithKline Safety Pharmacology Group entitled “Measurement of optical action potentials and calcium transients in hiPSC-derived cardiomyocytes using the novel Optopatch© fluorescent protein platform” (122).
Q-State also had a booth (125).
September 25, 2014 - Q-State Biosciences joins HESI Cardiac Safety Technical Committee
Q-State Biosciences joins HESI Cardiac Safety Technical Committee (CSC) and is now an official member of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative.
CiPA initiative is driven by HESI, the US Food & Drug Administration (FDA) and the Safety Pharmacology Society (SPS). Its goal is the establishment of early prediction of potential cardiac arrhythmias as a side effect of pharmaceuticals.
Q-State Biosciences will apply its proprietary all optical electrophysiology platform in hESC- or iPSC-derived cardiomyocytes for early compound screening.
September 22-24, 2014 - Q-State attends BioPharm America
Boston Mariott Colpey Place, Boston, MA.
September 12, 2014 - Optopatch on CNN!
This weekend CNN’s “Sanjay Gupta, MD” show will have a piece on Optopatch. Tune in on Saturday, September 13 at 4:30pm EST or on Sunday, September 14 at 7:30am EST.
September 8, 2014 - Q-State Biosciences to attend Safety Pharmacology Society Annual Meeting
Meet us at Marriott Wardman Park Hotel in Washington DC on October 19-22, 2014 (Booth 125).
September 5, 2014 - Q-State Biosciences co-founder Kevin Eggan gives a talk at Basel Stem Cell Network
Kevin's will give a talk entitled “iPS cells: From individual patients to unifying pathways underlying motor neuron degeneration” at BSCN in Basel, Switzerland on September 9.
August 12, 2014 - Q-State Biosciences co-founder Adam Cohen receives 2014 ACS Award in Pure Chemistry
The American Chemical Society Award in Pure Chemistry is awarded annually by the American Chemical Society (ACS) to recognize and encourage fundamental research in pure chemistry carried out in North America by young men and women.
August 12-13, 2014 – Q-State Biosciences attends CDI user group meeting
This event brings together thought leaders, customers, and commercial providers of assays & platforms to discuss ideas, showcase customer research, and share experiences to advance the use of iPS cell technology for drug discovery, disease research, and regenerative medicine.
Meet us at the Sheraton Boston Hotel in Boston, MA.
August 6, 2014 – Buzz around Kevin Eggan’s most recent publication on Amyotrophic Lateral Sclerosis (ALS)
The Boston Globe and Harvard Gazette underscore the importance of Kevin Eggan’s publication in advancing the field’s understanding of the underlying mechanisms involved in ALS. These findings could potentially lead to major advances in ALS drug discovery and treatment.
August 6, 2014 - Q-State Biosciences co-founder Kevin Eggan publishes on Amyotrophic Lateral Sclerosis (ALS) in Science Translational Medicine
Genetic validation of a therapeutic target in a mouse model of ALS. A-S de Boer et al., Science Translational Medicine, 6 August 2014, Vol. 6 no. 248 pp. 248ra104. DOI:10.1126/scitranslmed.3009351 248ra104
August 1st, 2014 - Q-State Biosciences co-founder Adam Cohen receives 2014 Blavatnik National Award
Adam Cohen, Q-State co-founder, has been named one of three winners of the 2014 Blavatnik National Awards, which honor young scientists and engineers who have demonstrated important insights in their respective fields and who show exceptional promise going forward.
July 31, 2014 - Q-State Biosciences co-founder Kevin Eggan has the cover of Nature Chemical Biology discovering a new approach for making oncogene free iPS cells with fewer mutations
Notch inhibition allows oncogene-independent generation of iPS cells. Justin Ichida et al., Nat Chem Biol. 2014 Aug;10(8):632-9. doi: 10.1038/nchembio.1552. Epub 2014 Jun 22.
June 22, 2014 - Q-State Biosciences co-founder Adam E. Cohen publishes on Optopatch in Nature Methods
All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins. Daniel Hochbaum et al., Nature Methods, 2014, doi:10.1038/nmeth.3000
View Supplementary Information (see especially movies 4 - 6)
June 22-26, 2014 - Q-State Biosciences attends BIO 2014
Meet us at San Diego Convention Center!
Q-State co-founder, Adam E. Cohen talks about "All-optical electrophysiology" during "Blavatnik Awards for Young Scientists" - Wednesday, June 25, Room 33A. Please join !
June 18-21, 2014 - Q-State Biosciences attends ISSCR 2014
Meet us at Vancouver Convention Centre (VCC)!
Poster 4014 presented June 20 - All optical electrophysiology identifies excitability deficits in ALS motor neurons. Evangelos Kiskinis, Joel M Kralj, David Marguiles, Adam Cohen and Kevin Eggan.
May 23, 2014 - New York Times magazine talks about Optopatch
The cover story in Sunday May 23rd New York Times magazine called "Can the Nervous System be Hacked?" features our co-founder Adam Cohen “Optopatch” machine among other technologies.
May 7-9, 2014 - Q-State Biosciences attends Hearth Rhythm 2014
Meet us in San Francisco.
May 7, 2014 - Q-State Biosciences starts cardiotoxicity collaboration
Q-State Biosciences began to test the effects of a panel of reference drugs on cardiac electrophysiology and calcium handling under optical pacing conditions. All-optical measurements yielded high-quality and high-throughput electrophysiological signatures, in stark contrast to the normative several months time needed for manual patch clamp recordings.
April 22, 2014 - Q-State Biosciences starts validation experiments
Q-State scientists started their validation of experiments on April 22nd. To ensure that measurement would be carried out with precision, six weeks of intensive validation were carried out on Q-state instrumentation and cell-culture capacity. During this time, internal studies were performed to ensure the system operated at its intended resolution, sensitivity and speed. Similar instruments have been designed and operated in the Cohen Lab at Harvard University for several years. Commercial specifications were established by analysis of the research-precursor instruments, and the Optopatch system was deemed complete when it met the desired specifications.
March 1, 2014 - Q-State Biosciences moves into headquarters
Q-State Biosciences moved into its new home located on Sidney Street, in the heart of Cambridge’s innovation hub. Starting with an empty space the team constructed an effective laboratory in only four weeks, laying the foundation for successful execution of external collaborations and internal research.
February 7, 2014 - Q-State receives SBIR grant from NINDS
Q-State receives Small Business Innovative Research (SBIR) grant from National Institute of Neurological Disorders and Stroke (NINDS) to develop instrumentation for "Optopatch: high-throughput all-optical electrophysiology".