top of page
Bringing electrophysiology to light
Voltage imaging
Votage indicator expressed in hiPSC-derived cardiomyocytes
Voltage indicator-eGFP sensor.
hiPSC-derived cardiomyocytes expressing voltage indicator-eGFP.
Fluorescence of voltage indicator reproduces conventional patch clamp electrophysiology - but with
1,000-fold higher throughput
Voltage indicator (red) closely follows membrane voltage (black) measured with a patch clamp.
The AP50 measured optically is linearly related to the AP50 measured via patch clamp.
Voltage indicator allows long-term measurement
Voltage indicator shows little phototoxicity and little photobleaching, allowing continuous measurements for > 20 minutes while preserving normal electrophysiology and excellent signal amplitude.
The core of the Q-State technology is a proprietary near infrared genetically encoded voltage indicator derived from a microorganism that lives in the Dead Sea. This protein reports membrane voltage with microsecond response times and sub-millivolt precision.
bottom of page